- October 19, 2022
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Lakewood Ranch High (4-2) lost 35-23 to Manatee High (5-1) on the road.
Braden River High (3-2) lost 50-27 to Bishop Moore High (3-3) on the road.
The Out-of-Door Academy (6-0) won 29-16 over Bell Creek Academy (1-5) on the road.
Parrish Community High (4-1) lost 14-9 to Southeast High (1-4) on the road.
Sarasota Christian (3-4) lost 47-42 to Lakeside Christian (4-2) on the road.
Riverview High, Sarasota High, Booker High and Cardinal Mooney High did not play.